WebApr 28, 2024 · The researchers tested this ASO in ATXN2-Q127, a mouse model of SCA2 that expresses a human ataxin-2 transgene with 127 CAG repeats in Purkinje cells in the cerebellum. At around 8 weeks of age, the mice develop motor difficulties, the firing of Purkinje cells wanes, and Purkinje cells degenerate. Scoles and colleagues injected … WebObjective: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by a CAG repeat expansion in the gene ataxin-2 (ATXN2). ATXN2 intermediate-length CAG …
Pulst Lab Research
WebOct 15, 2024 · Background. The ataxin-2 (ATXN2) gene contains a cytosine-adenine-guanine repeat sequence ranging from 13 to 31 repeats, but when surpassing certain thresholds causes neurodegeneration.Genetic alterations in ATXN2 other than pathological cytosine adenine guanine (CAG) repeats are unknown.. Methods/Results. We have … WebPurpose of review . To provide an update on the role of Ataxin-2 gene (ATXN2) in health and neurological diseases.Recent findings . There is a growing complexity emerging on … francis tucker actor
A Study to Assess the Safety, Tolerability, and Effect on Disease ...
WebMutations in the ATXN2 gene cause SCA2. The ATXN2 gene provides instructions for making a protein called ataxin-2. This protein is found throughout the body, but its function is unknown. Ataxin-2 is found in the … WebMar 1, 2024 · Furthermore, research has revealed a strong effect of ATXN2 expansion on Parkinson disease (PD) and the MSA-P subtype 9, and intermediate-expansion within ATXN1 or ATXN2 has been associated with ... WebSep 11, 2024 · Initial efforts to discover ATXN2 interacting proteins was by employing use of the yeast two-hybrid (Y2H) system, a method adopted by Dr. Scoles in the lab between ’95-‘96 to identify interactors to the NF2 protein (Scoles et al., 1998; Scoles et al., 2000; Scoles et al., 2006).By using Y2H we discovered the RNA binding protein ATXN2 binding … blank time card form