Ift88 cilia
Web15 apr. 2024 · Additionally, IFT88 knockdown in G0 leads to specific induction of G2/M transcriptional networks, and cells lacking cilia display enhanced activity of multiple cilium-associated signaling pathways, accompanied by an increase in protein synthesis, with a specific shift towards 4E-BP1-regulated translation.
Ift88 cilia
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WebImmunofluorescence analysis of IFT88 in HepG2 cells using a IFT88 monoclonal antibody ( Product # PA5-18467) at 10 µg/mL for1hr. The cells were paraformaldehyde fixed and permeabilized with 0.15% Triton. Primary incubation was followed by Alexa Fluor 488 secondary antibody (2 µg/mL) showing nuclear and Golgi/cytoplasmic staining. Web29 apr. 2013 · Several other studies similarly contradict the activation of Wnt-signaling solely due to cilia disruption; Ift88, Ift172 and Kif3a mutant mouse embryos and maternal-zygotic zebrafish ift88 mutants do not show altered canonical Wnt-signaling [90, 91], suggesting that results reflect tissue and developmental stage-specific discrepancies .
Web15 apr. 2024 · IFT88 Angiogenesis Cilium Cell migration Cell division Microtubule stability 1. Introduction Angiogenesis is a process that involves new vessels sprouting from pre … Web19 dec. 2024 · To determine whether aldosterone affects ciliary lengthening through its effects on IFT, we investigated protein levels and degradation of the core IFT complex B protein, IFT88 and the molecular motor, KIF3A, which are involved in anterograde transport and ciliary growth, respectively. 34, 35 Aldosterone treatment increased IFT88 protein …
Web31 dec. 2024 · We analyzed cochleae from three ciliopathy mouse models exhibiting different ciliogenesis defects: Intraflagellar transport 88 ( Ift88 ), Tbc1d32 (a.k.a. bromi ), and Cilk1 (a.k.a. Ick) mutants. These mutants showed multiple developmental defects including shortened cochlear duct and abnormal apical patterning of the organ of Corti. WebIFT88 (intraflagellar transport protein 88; also known as TG737 or TTC10) is a component of IFT particles and required for cilium biogenesis. Defects in IFT88/Tg737 lead to …
Web15 feb. 2010 · J Cell Sci (2010) 123 (4): 499–503. The primary cilium, which was first so named by Sergei Sorokin ( Sorokin, 1968 ), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest. Increasing evidence suggests that primary cilia are key coordinators of signaling pathways during …
Web14 okt. 2015 · Ift88 is an essential protein within cilia that has played a pivotal role in unveiling the function of cilia in mammalian development and disease . The Oak Ridge … does the bible say anything about dragonsWebIFT88 30 IFT88 is a component of anterograde IFT and is required for ciliogenesis,4 and thus ORPK mice have abnormally short or missing cilia,27 linking primary cilia and … does the bible say anything about ghostsWebGiven that intraflagellar transport (IFT) is essential for cilium assembly, we investigated the role of one of its main players, IFT88, in ciliary maintenance. We show that DmIFT88, the Drosophila melanogaster orthologue of IFT88, continues to move along fully formed sensory cilia, and that its acute knockdown in the ciliated neurons of the adult affects sensory … does the bible say anything about gamblingWebIFT88/primary cilia play a role in metabolic reprogramming in thyroid cancer cells. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured … does the bible say anything about halloweenWeb1 mrt. 2024 · Cilia of olfactory sensory neurons (OSNs) are the primary site of odor binding; hence, their loss results in anosmia, ... We utilized OSN-specific Ift88 knockout mice ... facility log オムロンWeb22 sep. 2024 · IFT88 was initially described for its role in mitotic spindle orientation in kidney cells and zebrafish embryos (Delaval et al., 2011). In this context, IFT88, in association … facility log bookWeb3 mei 2024 · Primary cilia can be specifically eliminated without affecting cell viability by inactivation of Ift88, a gene encoding an intraflagellar transport protein specifically required for ciliogenesis and ciliary maintenance ( 21 ). facility logistic heilbronn gmbh