2024 Klf4 senescence

Klf4 senescence

Author: xtyl

August undefined, 2024

WebMar 7, 2024 · Transcription factor enrichment analysis indicated a role for oxidative stress regulated factors (nuclear factor erythroid 2-related factor 2) in the differential transcriptome response but also... Webmodulators, moderators of cell senescence, or modulators of metabolism [3, 34, 35] and the functions of the small ... levels of OCT4 and KLF4 during somatic cell reprogram-ming [32]. Parnate, a lysine-specific demethylase inhibitor (LSD1),mediatesH3K4demethylation,enablingOct4and

Reprogramming with Small Molecules instead of Exogenous …

WebNov 9, 2014 · KLF4 regulates many gene expression, thus affects the process of cell proliferation, differentiation, and apoptosis. Recently, KLF4 was reported to induce … WebSep 13, 2016 · KLF4 regulates many gene expression, thus affects the process of cell proliferation, differentiation, and apoptosis. Recently, KLF4 was reported to induce … free printable fleece baby hat pattern

(PDF) Overexpression of KLF4 promotes cell senescence

WebMay 4, 2024 · Overexpression of KLF4 Attenuated senescence in AECs and KLF4 regulate TERT In order to further explore the role of KLF4 in TERT regulation, we used plko.1 … WebOct 23, 2005 · KLF4 ( GKLF / EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a … WebKLF4 regulates many gene expression, thus affects the process of cell proliferation, differentiation, and apoptosis. Recently, KLF4 was reported to induce senescence during the generation of... free printable flat cap pattern

Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4

The KLF4 tumour suppressor is a transcriptional …

WebDec 10, 2024 · This is dictated in part by upregulation of KLF4 signaling. Therefore, inhibiting hyperoxia-induced senescence via miR-34a-5p or KLF4 suppression may provide a novel … WebJan 27, 2012 · The transcription factor Krüppel-like factor 4 (KLF4) is an important regulator of cell-fate decision, including cell-cycle regulation, apoptosis, and stem cell renewal, and plays an ambivalent role in tumorigenesis as a tissue-specific tumor suppressor or oncogene. Here, we report that the Von Hippel-Lindau gene product, pVHL, physically … farmhouses for sale in scWebSep 2, 2010 · The oncogenic properties of KLF4 might be explained by transcriptional repression of p53 and hence bypassing of p53-mediated senescence and apoptosis pathways. 3 Furthermore, KLF4 together with Oct3/4, Sox2, and c-Myc is able to reprogram differentiated cells to pluripotent stem cells. 4 The tumor suppressor role of KLF4 in … free printable flat world map

"WebMay 31, 2016 · There are of course also reports that show opposite outcomes, i.e. faster aging: Senescence was accelerated in 3 cloned pigs of a genetically abnormal fetal fibroblast cell line . Genetic dysregulation also led to phenotypical abnormities in G0 and G1 generations of serial cloned pigs, but generations G2 and G3 were back to normal again [ … " - Klf4 senescence

Klf4 senescence

KLF4 regulates TERT expression in alveolar epithelial …

WebKlf4 methylated by Prmt1 restrains the commitment of primitive endoderm. Nucleic Acids Res. 2024 Feb 28. Zuo ZY, Yang GH, Wang HY, Liu SY, Zhang YJ, Cai Y, Chen F, Dai H, Xiao Y, Cheng MB, Huang Y, Zhang Y. 黄粤, A, 17.21. ... Comprehensive assessment of cellular senescence in the tumor microenvironment. Brief Bioinform. 2024 May 13. Wang X ... WebMay 5, 2024 · Klf4 is important in sustaining keratinocytes proliferation; silencing of KLF4 by RNA interference is sufficient to induce cellular senescence. During cellular senescence …

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WebThe present study aimed to explore the role and mechanism of KLF4 in angiotensin II (Ang II)-induced VSMC senescence. Methods The VSMC senescence mouse model was … WebIn order to determine whether KLF4 is involved in Hcy-induced endothelial cell senescence, western blotting and RT-qPCR were used to assess the expression levels of KLF4. As …

WebOct 1, 2024 · Cellular senescence, characterized by a progressive, ... /SM-MHC), myocardin (MYOCD) and calponin (CNN1). The mesenchymal phenotype is characterized by Kruppel-like factor 4 (KLF4) and CD34. The fibroblast-like phenotype is characterized by expression of fibronectin 1 (FN1) and collagen type Iα 1 chain (COL1A1). The macrophage-like … WebMay 4, 2024 · KLF4 prevented angiotensin II-induced smooth muscle cell senescence by enhancing autophagic activity Hongjie Xu, Hongjie Xu Department of Cardiovascular Surgery, Institute of Cardiac Surgery, Changhai Hospital, Naval Medical University, Shanghai, China Search for more papers by this author Manli Yu, Manli Yu

WebСенолітики (від слів senescence і -lytic, «руйнівний») відносяться до класу малих молекул, які можуть вони вибірково індукувати загибель старіючих клітин ... — Oct4, Klf4, ... WebDec 22, 2005 · Third, KLF4 was identified in a screen for genes whose products can prevent induction of senescence by an activated form of Ras (Ras V12) 40. Michael Ruppert's laboratory found that KLF4 is...

WebDec 23, 2024 · Senescence is a state of irreversible proliferative arrest, which cells undergo in response to a variety of detrimental stimuli, and is associated with changes in …

WebFeb 4, 2024 · Ocampo et al. ameliorated senescence and the aging phenotype by executing short‐term cyclic expression of Oct4, Sox2, Klf4, and c‐Myc in mice. Sarkar et al. transiently expressed OCT4, SOX2, KLF4, c‐MYC, LIN28, and NANOG in human cells, partially reversing cellular senescence and restoring aged tissue. Those actions removed the senescence ... free printable flashcards with picturesWebCited2 plays crucial roles in mouse embryonic stem cells self-renewal, the initiation of the somatic reprogramming process into induced pluripotent stem cells (iPSC) and the suppression of cell senescence. Here, we investigated the potential of farm houses for sale in scott county iowaWebDec 15, 2024 · FIGURE 2.Hyperglycemia-induced HUVEC senescence is KLF4 dependent. (A) KLF4, as measured by immunoblotting and qRT-PCR in HUVECs after transfection with siNC or siKLF4 for 48 h.(B) Cells were fixed and stained for SA-β-gal activity and the histogram represents the percentage of SA-β-gal-positive cells per microscopic field. Values … farm houses for sale in scotlandWebSenescence analysis was performed by β-galactosidase staining after 24 and 48 h. Controls were established using BM-MSC from healthy donors and used for senescence and gene expression assays. Gene expression was performed using RT-PCR for pluripotency genes, such as SOX2, POU5F1, NANOG, and KLF4. free printable flat stanley templateWebStress-induced senescence in vitro. In vitro, premature senescence can result from inadequate culturing conditions. When cells are explanted from an organism and placed in culture, they have to adapt to an artificial environment, characterized by abnormal concentrations of nutrients and growth factors and the presence of ambient O 2 levels, as … farmhouses for sale in shropshireWebMay 5, 2024 · Klf4 is important in sustaining keratinocytes proliferation; silencing of KLF4 by RNA interference is sufficient to induce cellular senescence. During cellular senescence … free printable fleece dog sweater patternWebKrüppel-like factor 4 (KLF4), a protein transcription factor, is involved in a variety of cellular processes and plays an important role in the maintenance of cellular stemness. ... Cellular senescence is often accompanied by the generation of the senescence secretory phenotype (SASP), which in IPF senescent fibroblasts includes pro ... free printable fleece hat pattern for adults