2024 Lamp2a是什么

Lamp2a是什么

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August undefined, 2024

Tīmeklis利用工程化胞外体的亲本细胞方法，最常见的将蛋白质引导到胞外体表面的方法是使用胞外体信号肽。例如，溶酶体相关膜蛋白2b（Lamp2b）是具有信号肽的胞外体表面蛋白。一种基于Lamp2b的融合蛋白可用于在表面显示狂犬病病毒糖蛋白（RVG），当这些胞外体被系统地给予时，表面展示的RVG导致这些胞外体在小鼠的神经元和大脑中积聚 … Tīmeklis2024. gada 25. marts · Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process that is dependent on the membrane protein LAMP2A. Moreover, we demonstrate that this mechanism is independent of the ESCRT machinery but dependent on HSC70, …

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TīmeklisLAMP分别代表什么？ · L代表服务器操作系统使用Linux · A代表网站服务使用的是Apache软件基金会中的httpd的软件 · M代表网站后台使用的数据库时MySQL数据库 · P代表网站是使用PHP/Perl/Python等语言 … TīmeklisBackground: Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. Methods: Mouse tumor models and cancer patients' samples were … philhealth olongapo contact number

Direct homophilic interaction of LAMP2A with the two-domain ...

Tīmeklis2024. gada 7. nov. · LAMP2A possesses a highly glycosylated luminal region that is common to all LAMP2 isoforms and a specific 11-amino-acid-long cytosolic C-terminal tail . By virtue of this particularity, LAMP2A (but neither of the 2 other isoforms, LAMP2B and LAMP2C), participates in CMA, which facilitates selective import and … Tīmeklis2024. gada 24. apr. · 这些作者表示，人们在一生中产生相同数量的lamp2a受体，不过，这些受体随着年龄的增加而退化得更快，因此老年人往往有较少的受体用于将不需要 ... TīmeklisLAMP2. Lysosome-associated membrane protein 2 ( LAMP2 ), also known as CD107b ( C luster of D ifferentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins . The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides … philhealth ohat package

SciAdv丨LAMP2A介导了蛋白质向外泌体的分选和包装 - 外泌体资 …

Tīmeklis2024. gada 25. marts · LAMP2A originates from the alternative splicing of the LAMP2 gene, which contains nine exons, including three different splice variants of the exon 9 (A, B, and C) . All splice variants share a common luminal domain but contain distinct cytosolic and transmembrane regions. Tīmeklis2024. gada 1. maijs · The structure of LAMP2A comprises a large lumenal domain composed of two homologous subdomains (N-domain and C-domain, both with the β-prism fold), a transmembrane domain, and a short cytoplasmic tail. Although the homophilic interaction between LAMP2A molecules and the interaction between … philhealth olongapo officeTīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. philhealth online application 2021

"TīmeklisLAMP2A functions as a receptor of chaperone-mediated autophagy (CMA), in which cytoplasmic proteins are transported into lysosomes for degradation [ 10 ]. LAMP2B is highly expressed in human cardiomyocytes, where its deficiency impairs the autophagosome-lysosome fusion to cause the cardiomyopathy in Danon disease [ … " - Lamp2a是什么

Lamp2a是什么

LAMP2A regulates the loading of proteins into exosomes

TīmeklisLAMP2a Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。 Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。 TīmeklisLAMP2a degrades PRDX1 (peroxiredoxin 1) and CRTC1 (CREB-regulated transcription coactivator 1) to promote macrophage pro-tumorigenic activation. Interpretation: Our study suggests that tumor cells utilize LAMP2a-PRDX1/CRTC1 axis to modulate TAMs activation and promote tumor growth, reveals the role of LAMP2a in macrophage …

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TīmeklisLAMP2A was immunoprecipitated from 1mg of RAW 264.7 (Mouse macrophage cells transformed with Abelson murine leukemia virus) whole cell lysate with ab125068 at 1/100 dilution. Western blot was performed from the immunoprecipitate using unpurified ab125068 at 1/2000 dilution. Tīmeklis2024. gada 18. marts · LAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C. LAMP2B is the predominant isoform expressed in cardiomyocytes. This study evaluates the efficacy of human LAMP2B gene transfer using a recombinant adeno-associated virus 9 carrying human LAMP2B (AAV9.LAMP2B) in a Lamp2 knockout (KO) mouse, …

TīmeklisAnti-LAMP2A antibody [EPR4207 (2)] - Lysosome Marker (ab125068) Research with confidence – consistent and reproducible results with … Tīmeklis2014. gada 12. dec. · National Center for Biotechnology Information

TīmeklisLAMP2 lysosomal associated membrane protein 2 [ (human)] Gene ID: 3920, updated on 7-Feb-2024 Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. Tīmeklis2024. gada 22. sept. · LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downregulation may be exploited therapeutically. We …

TīmeklisLAMP2蛋白；溶酶体关联膜蛋白2 (LAMP2)重组蛋白英文名称：Recombinant Lysosomal Associated Membrane Protein 2 (LAMP2) CD107-B; CD107b; LAMP-2C; LAMPB; LGP96; Lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B 来源：原核表达宿主：E.coli 规格：10μg 50μg 200μg 1mg 5mg 内毒素水 …

Tīmeklis2024. gada 24. nov. · HEK293 cells were transfected with myc-LAMP2A (wt) or (mt, T211A and T213A) for 40 h, and proteins were collected for IP with anti-myc for p38 MAPK in vitro kinase assay (top left); and SN4741 ... philhealth online account log inTīmeklisCMA is a selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein 2A), a mammal and bird-specific membrane glycoprotein that translocates cytosolic proteins containing a KFERQ-like peptide motif across the lysosomal membrane. philhealth online access form 2022Tīmeklis2024. gada 28. marts · 总而言之，研究人员提出了lamp2a在与escrt无关的过程中介导蛋白质包装到外泌体中，并且涉及hsc70对活性kferq序列的识别。 CD63、Syntenin-1、Alix、Rab31和神经酰胺等内体蛋白似乎是这种选择性包装所必需的，尽管它们的作用尚 … philhealth old rateTīmeklisABSTRACT. LAMP1 (lysosomal-associated membrane protein 1) and LAMP2 are the most abundant protein components of lysosome membranes. Both LAMPs have common structures consisting of a large lumenal domain composed of two domains (N-domain and C-domain, which are membrane-distal and -proximal, respectively), both … philhealth ofw paymentTīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. philhealth online appointment cavite philhealth online application numberTīmeklisLAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. philhealth online access form 2021